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Adult receives CRISPR-edited cells to fight cancer

Signal of change / Adult receives CRISPR-edited cells to fight cancer

By Anne-Louise Vernes / 04 Jan 2017

In October 2016, scientists from Sichuan University in Chengdu, West China, became the first in the world to inject an adult human with cells that have been genetically edited using the CRISPR/Cas9 technique.

The patient involved had aggressive lung cancer, and researchers were able to extract the patient’s immune cells from a blood sample and use CRISPR editing to disable a gene in them.

The gene in question was for a protein called PD-1, which normally slows down a cell’s immune response, thus allowing the cancer to grow out of control.

The PD-1-free immune cells cultured in the lab were injected back into the patient, and the aim is that they’ll now proliferate in the patient’s body and attack and destroy cancerous cells.

Although it is still early days, lead researcher Lu You said the initial treatment went well, and the patient is now ready for a second injection. Across the duration of the trial, the team aims to treat ten people with between two to four injections of genetically edited immune cells in each.

So what?

The US plans for a similar trial on various cancers in humans to commence in early 2017, whilst a group at Peking University in Beijing hopes to start three clinical trials in March 2017 using CRISPR against bladder, prostate and renal-cell cancers.

Experts believe that this activity into CRISPR research has accelerated the biomedical race to get efficient genetic editing into the clinic across the world.

“I think this is going to trigger ‘Sputnik 2.0’, a biomedical duel on progress between China and the United States”, argued Carl June, an immunotherapist from the University of Pennsylvania and a scientific adviser on next year's US CRISPR trial. “[This is] important since competition usually improves the end product,” he says.

The danger however, is that during this race not enough time will be devoted to reflecting upon the unforeseen consequences of human genetic modification. The uncertainty involved in this science should not be overlooked, notably that the capacity to engineer ecosystems to be rid of disease could have unpredictable effects on future generations.


What might the implications of this be? What related signals of change have you seen?

Wow, this is very impressive. I imagine that a successful cancer treatment will really change people's minds about genetic modification..
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